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Jim Wooley searches for the missing LINQ

tell Jim Wooley we need a better photo! Jim Wooley, leader of the Atlanta Visual Basic Study Group, presented to the Atlanta C# User Group last night.  Or should I say that he presented to the newly re-branded Atlanta Cutting Edge User Group last night?  Either way, Jim Wooley presented his patented “Missing Linq” presentation to the group.  This is Jim’s third or fourth time presenting this particular topic, which has been on tour to regional code camps, and his familiarity with the material showed through in his insightful and well thought-out slide deck and accompanying demos.  This was my first time seeing this material as I missed the Atlanta Code Camp and have been too lame to make it to any of the other region’s code camps like the upcoming camp in Greenville SC (next week!!!). 

What can I say about the content of the presentation?  LINQ (Language Integrated Query) is a new “unified” programming model which is designed to let developers work with different types of data (relational = SQL = ADO, hierarchical = XML = XML/XPath, and object based = custom) using the same type of syntax.  There seem to be two major goals behind this initiative.  First – the syntax for todays coding is pretty domain specific and not very declaritive in nature.  It’s not always easy to tell what kind of data you’re working with.  I’ve stolen a screenshot from Jim’s slide deck here:

Pre-xlinq

Using the new syntax provided by the LINQ implementations, you can take the above code (in screenshot) and re-do it so that you have this style code (stolen from demo code):

            XElement x = new XElement("LinqEssentials",
                       new XElement("Category", "LINQ"),
                       new XElement("Category", "DLINQ"),
                       new XElement("Category", "XLINQ"));
            XElement y = new XElement("LanguageFeatures");
            y.Add(new XElement("release", new XAttribute("version", "2.0"),
                new XElement("feature", "Generics"),
                new XElement("feature", "Iterators"),
                new XElement("feature", "Anonymous Delegates"),
                new XElement("feature", "Nullable Types")
                ));
            y.Add(new XElement("release", new XAttribute("version", "3.0"),
                 new XElement("feature", "Implicit Types"),
                 new XElement("feature", "Extension methods"),
                 new XElement("feature", "Lambda Expressions"),
                 new XElement("feature", "Object initializers"),
                 new XElement("feature", "Anonymous Types"),
                 new XElement("feature", "Expression Trees")
                 ));
            y.Add(new XElement("release", new XAttribute("version", "9.0"),
                new XElement("feature", "dynamic interfaces"),
                new XElement("feature", "dynamic identifiers"),
                new XElement("feature", "XML Literals")
                ));
            XElement z = new XElement("LinqRocksBecause");
            z.Add(x);
            z.Add(y);

This is much nicer b/c you can see the elements in a declaritive fashion – you can tell what the XML document contains without having to read through the CRUD of constructing an XML document.  VB is even easier to read:

       Dim val = <XLinqRocksBecause version=<%= CodeCamp %>>
                      <LinqEssentials>
                          <Category>LINQ</Category>
                          <Category>DLINQ</Category>
                          <Category>XLINQ</Category>
                      </LinqEssentials>
                      <LanguageFeatures forDate=<%= Today() %>>
                          <release version="2.0">
                              <feature>Generics</feature>
                              <feature>Iterators</feature>
                              <feature>Anonymous Delegates</feature>
                              <feature>Nullable Types</feature>
                          </release>
                          <release version="3.0">
                              <feature>Implicit Types</feature>
                              <feature>Extension methods</feature>
                              <feature>Lambda Expressions</feature>
                              <feature>Object initializers</feature>
                              <feature>Anonymous Types</feature>
                              <feature>Expression Trees</feature>
                          </release>
                          <release version="9.0">
                              <feature>dynamic interfaces</feature>
                              <feature>dynamic identifiers</feature>
                              <feature>XML Literals</feature>
                          </release>
                      </LanguageFeatures>
                  </XLinqRocksBecause>

The second major goal of the LINQ initiative is to give developers a unified way to query into these different types of structured data.  This is accomplished with a set of extension methods that give the developer a very SQL type of language syntax for queries.  Here is an example query.

            var results = from f in new DirectoryInfo(@"C:\windows").GetFiles()
                          where f.extension == ".exe"
                          select new{f.Name, f.LastAccessTime};
Notice the semicolon – that’s C# code right there.  Extremely readable!  LINQ offers the ability to join in multiple data sources, change the sort criteria (orderby) and change the output values (including aggregations and calculations).  This query syntax will work with SQL data, flat file data, file system object data (as above), XML data, and more. 

Jim’s presentation was excellent and he’s going to present it a few more times at various user groups and code camps.  Keep up with his blog to learn more.  Five stars!

Published 06-09-2006 08:06 by Matt Ranlett
Filed Under: , ,

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Jim Wooley said:

Thanks for the nice writeup. If you missed the presentation it is similar to the one I did at the Atlanta code camp. We recorded that presentation and the webcast is available at http://devauthority.com/files/13/jwooley/entry1376.aspx. Also, the slide deck and demos are basically the same as those from the Jacksonville CC which are available at http://devauthority.com/files/13/jwooley/entry2407.aspx
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May 8, 2007 2:00 PM
 

RobSeidman said:

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urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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solomon said:

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Bye
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RobSeidman said:

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May 10, 2007 9:17 AM
 

RobSeidman said:

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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
May 10, 2007 7:09 PM
 

RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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RobSeidman said:

On Friday, the first day after Merck's loss of patent exclusivity for the statin Zocor, FDA approved three generic versions of the drug, the Wall Street Journal reports. Teva Pharmaceutical Industries and Ranbaxy Pharmaceuticals for the next 180 days will have exclusive rights to sell generic Zocor, generically known as simvastatin. Teva will sell 5-, 10-, 20- and 40-milligram versions, while Ranbaxy will sell an 80-milligram pill. The generic versions are available at a price that is about 30% less than Zocor's. In addition, Dr. Reddy's Laboratories will sell all five dosages of simvastatin under an agreement with Merck to be the authorized generic manufacturer of the drug. FDA's decision came hours after U.S. District Judge Royce Lamberth denied a motion by Sandoz, Novartis' generic drug unit, to delay the agency's approval of generic versions. Lamberth said the delay could damage the finances of Teva and Ranbaxy and could restrict the public's access to affordable drugs (Won Tesoriero/Zhang, Wall Street Jo
urnal, 6/24). FDA estimated that generic versions of Zocor and other generic drugs approved this week -- versions of baldness drug [url=http://cheap-propecia-store.blogspot.com/]Propecia[/url], prostate drug Proscar and epilepsy treatment Lamictal -- could result in $1 billion per year in savings. Rob Seidman, chief pharmacy officer for WellPoint, said 12 million Medicare Part D beneficiaries who use statins could generate $8.2 billion in savings per year if they switched to generic versions (CQ HealthBeat, 6/23).
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The popular hair-growth drug finasteride, taken by millions of balding men, artificially lowers the results of the prostate-specific antigen (PSA) test, the standard screening test for prostate cancer, a multicenter study has found.

The study, involving 308 men ranging in age from 40 to 60 years old, is available online in the British medical journal The Lancet and is scheduled to be published after Jan. 1, 2007. The study calls for new clinical guidelines for primary-care physicians, dermatologists and urologists to account for the role of finasteride, known as Propecia when used for hair loss, while evaluating PSA results.

"It's not universally known that finasteride lowers PSA levels in younger men who take it for hair growth," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern Medical Center and co-principal investigator of The Lancet study, along with Dr. Anthony D'Amico of Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston. "It is important for physicians to know that many young men take Propecia and that their PSA level is lowered artificially. Doctors need to adjust the PSA interpretation by multiplying it times two for these men."

Finasteride was initially developed in the 1990s for the treatment of benign prostatic hyperplasia (BPH), better known as enlarged-prostate disease, and was first approved by the U.S. Food and Drug Administration for this use. Patients with BPH must strain to pass urine and feel the urge to urinate frequently. BPH can lead to the inability to urinate and urinary tract infection.

In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

"The impact of finasteride on PSA levels is significant," said Dr. Roehrborn. "This needs to be realized by all internists, family-care doctors, dermatologists - anybody who writes prescriptions for male-pattern hair loss."

Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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HarryHines said:

The popular hair-growth drug finasteride, taken by millions of balding men, artificially lowers the results of the prostate-specific antigen (PSA) test, the standard screening test for prostate cancer, a multicenter study has found.

The study, involving 308 men ranging in age from 40 to 60 years old, is available online in the British medical journal The Lancet and is scheduled to be published after Jan. 1, 2007. The study calls for new clinical guidelines for primary-care physicians, dermatologists and urologists to account for the role of finasteride, known as Propecia when used for hair loss, while evaluating PSA results.

"It's not universally known that finasteride lowers PSA levels in younger men who take it for hair growth," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern Medical Center and co-principal investigator of The Lancet study, along with Dr. Anthony D'Amico of Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston. "It is important for physicians to know that many young men take Propecia and that their PSA level is lowered artificially. Doctors need to adjust the PSA interpretation by multiplying it times two for these men."

Finasteride was initially developed in the 1990s for the treatment of benign prostatic hyperplasia (BPH), better known as enlarged-prostate disease, and was first approved by the U.S. Food and Drug Administration for this use. Patients with BPH must strain to pass urine and feel the urge to urinate frequently. BPH can lead to the inability to urinate and urinary tract infection.

In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

"The impact of finasteride on PSA levels is significant," said Dr. Roehrborn. "This needs to be realized by all internists, family-care doctors, dermatologists - anybody who writes prescriptions for male-pattern hair loss."

Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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May 31, 2007 8:12 PM
 

HarryHines said:

The popular hair-growth drug finasteride, taken by millions of balding men, artificially lowers the results of the prostate-specific antigen (PSA) test, the standard screening test for prostate cancer, a multicenter study has found.

The study, involving 308 men ranging in age from 40 to 60 years old, is available online in the British medical journal The Lancet and is scheduled to be published after Jan. 1, 2007. The study calls for new clinical guidelines for primary-care physicians, dermatologists and urologists to account for the role of finasteride, known as Propecia when used for hair loss, while evaluating PSA results.

"It's not universally known that finasteride lowers PSA levels in younger men who take it for hair growth," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern Medical Center and co-principal investigator of The Lancet study, along with Dr. Anthony D'Amico of Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston. "It is important for physicians to know that many young men take Propecia and that their PSA level is lowered artificially. Doctors need to adjust the PSA interpretation by multiplying it times two for these men."

Finasteride was initially developed in the 1990s for the treatment of benign prostatic hyperplasia (BPH), better known as enlarged-prostate disease, and was first approved by the U.S. Food and Drug Administration for this use. Patients with BPH must strain to pass urine and feel the urge to urinate frequently. BPH can lead to the inability to urinate and urinary tract infection.

In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

"The impact of finasteride on PSA levels is significant," said Dr. Roehrborn. "This needs to be realized by all internists, family-care doctors, dermatologists - anybody who writes prescriptions for male-pattern hair loss."

Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
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In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

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Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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"It's not universally known that finasteride lowers PSA levels in younger men who take it for hair growth," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern Medical Center and co-principal investigator of The Lancet study, along with Dr. Anthony D'Amico of Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston. "It is important for physicians to know that many young men take Propecia and that their PSA level is lowered artificially. Doctors need to adjust the PSA interpretation by multiplying it times two for these men."

Finasteride was initially developed in the 1990s for the treatment of benign prostatic hyperplasia (BPH), better known as enlarged-prostate disease, and was first approved by the U.S. Food and Drug Administration for this use. Patients with BPH must strain to pass urine and feel the urge to urinate frequently. BPH can lead to the inability to urinate and urinary tract infection.

In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

"The impact of finasteride on PSA levels is significant," said Dr. Roehrborn. "This needs to be realized by all internists, family-care doctors, dermatologists - anybody who writes prescriptions for male-pattern hair loss."

Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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"It's not universally known that finasteride lowers PSA levels in younger men who take it for hair growth," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern Medical Center and co-principal investigator of The Lancet study, along with Dr. Anthony D'Amico of Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston. "It is important for physicians to know that many young men take Propecia and that their PSA level is lowered artificially. Doctors need to adjust the PSA interpretation by multiplying it times two for these men."

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In 1997 the FDA approved finasteride for the treatment of male-pattern baldness. While Propecia is administered at 1 milligram per day, patients who take the finasteride drug Proscar for BPH get a five times higher dosage, 5 mg per day.

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Researchers have known for years that the same testosterone metabolism responsible for prostate growth also causes male-pattern baldness (called androgenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT.

The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana, Louisiana, Minnesota, New York, North Carolina, Oregon, Texas and Virginia.

The data in The Lancet study are derived from a study Dr. Roehrborn conducted with Merck & Co., Inc. in 2000. Dr. Roehrborn, discussing the reasons to publish this report now, said: "The data are published now out of recognition that there was an acknowledged gap in the primary-care community about the impact of Propecia on PSA levels. When doctors ask for their patients' medical history, they need to ask if they have taken any drugs for hair loss, and the doctors need to multiply the PSA readings by two."

The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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The current study also was funded by Merck & Co., Inc.

About UT Southwestern Medical Center
UT Southwestern Medical Center, one of the premier medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. Its more than 1,400 full-time faculty members - including four active Nobel Prize winners, more than any other medical school in the world - are responsible for groundbreaking medical advances and are committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 89,000 hospitalized patients and oversee 2.1 million outpatient visits a year.
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December 15, 2007 10:46 AM
 

aserty said:

January 14, 2008 2:43 AM
 

aserty said:

January 14, 2008 2:52 AM
 

aserty said:

January 14, 2008 3:17 AM
 

aserty said:

January 14, 2008 5:29 AM
 

dmvnjudi said:

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January 16, 2008 11:01 AM
 

floownsen said:

January 16, 2008 8:14 PM
 

bob said:

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January 17, 2008 6:13 PM
 

razer22 said:

January 18, 2008 12:47 PM
 

bob said:

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January 20, 2008 3:25 PM
 

bob said:

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January 21, 2008 3:03 AM
 

qasder said:

January 22, 2008 10:52 AM
 

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January 22, 2008 2:09 PM
 

wer45 said:

January 23, 2008 7:29 AM
 

pokna said:

January 23, 2008 7:32 PM
 

uriklo said:

January 24, 2008 1:06 AM
 

welop said:

January 24, 2008 10:11 AM
 

pokna said:

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January 24, 2008 1:02 PM
 

bob said:

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January 24, 2008 6:39 PM
 

qasder said:

January 24, 2008 7:03 PM
 

faudiomma said:

January 25, 2008 5:47 AM
 

wer45 said:

January 26, 2008 4:14 PM
 

wer45 said:

January 26, 2008 5:49 PM
 

porlan said:

January 26, 2008 9:17 PM
 

wer45 said:

January 27, 2008 11:27 PM
 

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January 28, 2008 7:36 AM
 

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January 28, 2008 6:12 PM
 

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January 28, 2008 9:50 PM
 

uriklo said:

January 31, 2008 7:22 PM
 

lohutr said:

February 1, 2008 11:41 AM
 

wer45 said:

February 16, 2008 2:36 PM
 

lohutr said:

February 17, 2008 1:21 PM
 

uriklo said:

February 17, 2008 1:25 PM
 

uriklo said:

February 17, 2008 2:41 PM
 

lohutr said:

February 17, 2008 2:46 PM
 

welop said:

February 17, 2008 6:51 PM
 

ccvdre said:

February 17, 2008 10:38 PM
 

pokna said:

February 18, 2008 1:13 PM
 

girtib said:

February 18, 2008 2:50 PM
 

porlan said:

February 18, 2008 4:22 PM
 

qasder said:

February 18, 2008 5:55 PM
 

girtib said:

February 18, 2008 7:38 PM
 

qasder said:

February 18, 2008 11:08 PM
 

lohutr said:

February 19, 2008 2:47 AM

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About Matt Ranlett

One of the two original Atlanta .NET Regular Guys, Matt fills his free time by helping to run several Atlanta area user groups, the Atlanta Code Camps, and works as one of the two INETA co-Vice Presidents of Technology
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